Crimean-Congo hemorrhagic fever (CCHF) is an acute and severe tick-borne viral disease presenting with fever and hemorrhage. Since 2002, CCHF cases have been observed in Turkey, and the cases have significantly increased over the years. Most of the cases are reported from hinterland of the Black Sea region and in a large geographical area between North Central and Northeastern Anatolia, especially during spring and summer. If people, especially those living in rural areas or dealing with agriculture and stockbreeding, have complaints of acute fever, headache, abdominal pain, nausea, vomiting, and rash, their history of tick contact should be reviewed and CCHF should be considered. In this study, we present two cases from the Eskisehir region who admitted with non-specific symptoms and different preliminary diagnoses, and who were later diagnosed with CCHF