A novel excipient was prepared from natural resources and bio-wastes such as sodium silicate, brine and date palm cellulose. The prepared excipient was water-insoluble silicate salt precipitated in date palm cellulose (WISS-DPC). The aim of this study was to evaluate the potential of this new substance as a tablet excipient. Diclofenac sodium and paracetamol tablets were manufactured using direct compression and wet granulation methods, respectively. The surface of the tablets was studied using AFM and SEM. FTIR and DSC provided a guarantee of compatibility of the excipient with the model drugs. The prepared tablets passed Pharmacopeial and Non-Pharmacopeial tests. Tablets prepared from WISS-DPC were harder, had rapid disintegration and rapidly dissolved compared to those produced from microcrystalline cellulose. The compactability of WISS-DPC was not affected by dilution with drugs or wet granulation. This new excipient could be used in pharmaceutical industry
