Toxoplasmosis is a disease caused by an obligate intracellular protozoan parasite Toxoplasma gondii. Approximately one-third of the world population is infected with this parasite. Several studies have examined the causes of human infertility in the Middle East. A high proportion of secondary infertility and a great contribution of the female factor was the major finding in most of these studies. In this study, we aim to explore the relationship between Toxoplasma gondii seropositivity and female infertile patients. Serum samples from 83 female patients visiting the infertility clinic and 57 normal prim gravid females attending the ANC clinic were collected during the year 2014. Serum samples were analyzed for anti-Toxoplasma IgG by chemiluminescent microparticle immunoassay (CMIA) technology. Patients visiting the infertility clinic, aged from 18-40 years (x=29.7) while normal prim gravid females attending the ANC clinic aged from 18-38 (x=26.1). Of the 83 samples collected from patients visiting the infertility clinic, 15 samples were positive for anti-Toxoplasma IgG while only 2 samples (out of 57) collected from normal prim gravid females attending the ANC clinic were positive. There was a statistically significant correlation between positive anti-Toxoplasma IgG and infertility (p<0.01). We suggest considering the presence of anti-Toxoplasma antibodies in serum of young females as an indicator for possible future infertility
