A comparative analysis of neurological manifestations in patients with acute ixodic tick-borne borreliosis (ITB) and patients with ITB associated with chronic opisthorchiasis has been carried out. It has been found that at ITB in the acute phase, nearly all parts of the nervous system are involved in the pathological process. Diseases of central parts of the nervous system were found in 86.7% patients with the monoinfection and in 96.7% patients with ITB associated with chronic opisthorchiasis, diseases of the vegetative part were found in 75.0 and 83.3% patients, and peripheral failures were found in 18.3 and 48.3% patients, respectively. In the structure of neurological pathology of the acute stage of ITB with chronic opisthorchiasis, the prevalence of the combined disease of different parts of the nervous system (93.3%), the more frequent occurrence (96.7%) and higher intensity of headaches (more than 4 points by the visual analog scale), vertigo (76.7%), cognitive failures (35.0%), signs of the vegetative disfunction syndrome (95.0%), and peripheral neuropathy (48.3%) were diagnosed
