Pacemaker lead endocarditis was diagnosed in two different patients. Causative microorganism was Staphylococus aureus and Staphylococcus epidermidis in the first and the second patient respectively. Patients were treated with antibiotics including cefazoline 3 x 2 g intravenous (IV) plus gentamicin 3 x 1 mg/kg
IV and rifampicin 3 x 300 mg oral, for 8 weeks and with the surgical removal of lead system. Clinical aspects, treatment options and diagnostic criteria of pacemaker lead endocarditis were discussed