Cyclospora cayetanensis is a frequently reported microorganism which causes diarrhea in both immunocompromised and immunocompetent patients. Despite new information on this emerging pathogen, significant gaps remain in our knowledge. There is a need to accurately diagnose and get information because the coccidian parasites are nearly never diagnosed, even upon the clinician’s request. Two immunocompetent patients with Cyclospora cayetanensis infections were presented and literatur was reviewed in this manuscript