Diabetic foot has a complicated pathogenesis and is a clinically variable situation that can range from minor vascular and neuropathic lesions to osteomyelitis and necrosis, which result in amputation; this non-stable disorder appears in the inframalleolar region. The risk factors are the duration of diabetes, improper foot hygiene, minor trauma, presence of smoking and alcohol use, peripheral neuropathy, peripheral angiopathy, and history of diabetic foot and immune system deficiency. Diabetic foot infections are commonly polymicrobial. We present in this study the case of a 65-year-old male farmer with diabetic foot who had several other underlying disorders affecting several systems. Diabetic foot (right) initiated from the lateral region of the fourth and fifth metatarsals and extended to the plantar surface, and had a purulent, deep, ulcerous soft tissue involvement. The patient was evaluated as grade III according to Wagner classification with the etiology of extended spectrum beta-lactamase positive Escherichia coli and Aeromonas sobria. He is under a multidisciplinary treatment with ertapenem