Introduction: Metabolic syndrome is characterized as, have at least 3 of the following 5 criteria: high waist circumference, high blood pressure, high Triglyceride, low HDL (High Density Lipoprotein), and elevated Fasting Blood Glucose. The International Diabetes Federation estimates that 25% of the world's population has metabolic syndrome. Specially, metabolic syndrome is more prevalence in depressed people and other psychiatric patients, but some studies do not confirm it. So, we decided to evaluate the association between metabolic syndrome criteria and depression as a most common psychiatric disorder. Method: Our study was a cross sectional design of 130 participants aged 18-65 years. We assessed the metabolic syndrome based on International Diabetes Federation criterion and depression by using the criterion of DSM-IV. Results: After an adjustment for important confounders (Physical activity, calorie intake, history of depression, the depression score, menopausal status, body mass index and dietary patterns) depressed patients significantly had more waist circumference. Conclusion: Maybe visceral obesity results in depression or vice versa. So, we suppose more studies to clarify this relationship
