BLOOD LEVELS OF FATTY ALDEHYDES IN CORONARY HEART DISEASE AND ATHEROSCLEROSIS

Abstract

Aim. To investigate the levels of fatty aldehydes and oxidised fatty acid radicals in erythrocytes and plasma lipids among patients with atherosclerosis and coronary heart disease (CHD). Material and methods. The study included patients with diagnosed CHD and coronary artery atherosclerosis, as well as healthy volunteers (controls). The levels of fatty aldehydes and oxidised fatty acid radicals were assessed using the capillary gas-liquid chromatography method. Results. CHD patients demonstrated elevated erythrocyte levels of fatty aldehydes and oxidised fatty radicals, as well as an increased relative content of fatty aldehydes in plasma lipids. Conclusion. Blood acidosis could play an important role in the elevation of fatty aldehyde levels in erythrocytes among patients with atherosclerosis and myocardial ischemia