Aim: Epidermal growth factor (EGF) and epidermal growth factor
receptor (EGFR) play an important role in the regulation of cell growth,
survival, migration, apoptosis, proliferation, and differentiation. We aimed to
investigate the presence of EGF (+61A/G) and EGFR R497Kpolymorphisms in
patients with inflammatory bowel disease (IBD) and their associations with
clinical features of the patients.Methods: This case-control study included 91 IBD patients (45
Crohn’s disease (CD) patients and 46 ulcerative colitis (UC) patients) and 129
healthy controls (HC). EGF and EGFR were
genotyped by polymerase chain reaction
and restriction fragment length polymorphism techniques to elucidate their
association with clinical outcomes. The disease activity for UC and CD were
assessed by Truelove-Witts index (TW) and Crohn's disease activity index
(CDAI), respectively. The Montreal classification was used for disease
involvement and behavior.Results: EGFR497 AA genotype was significantly decreased in patients with
UC compared with CD and HC. In addition, the patients with UC who had EGF +61 A
allele had increased risk of moderate and severe disease (p=0.28; OR= 3.13; 95%
CI=0.34-28.73). The patients with CD who had the EGF61 AG genotype were
found to increased risk for the presence of penetrating disease (p=0.14; χ2=5.59; OR=5.00;
95% CI=1.26-19.83). EGF +61 A genotype carriers also had higher CDAI scores
(p=0.19; OR=4.00; 95% CI=0.44-36.14). In addition, A+ carriers were also found
to have higher requirement for anti-TNF treatment (p=0.11; OR=5.0; 95% CI=0.56-44.4).
Conclusion: In this study,
EGFR 497 AA genotype was found to decrease significantly in patients with UC
compared to HC and CD patients. To enlighten the mechanism, further studies with
larger sample groups are needed to clarify the role of the EGF (+61A/G) and
EGFR R497K genes polymorphism, and development of the etiology and pathogenesis
of IBD