D Hekmatpou,1 E Mohammad Baghban,1 L Mardanian Dehkordi2 1Nursing Department, Arak University of Medical Sciences, Arak, Iran; 2Nursing Department, Isfahan University of Medical Sciences, Arak, Iran Background: Care for stroke patients at home is a very complicated and tough activity. Objective: The study was conducted to examine the effect of patient care education on burden of care and quality of life of caregivers of stroke patients. Materials and methods: The study was an educational trial conducted on 100 caregivers of the stroke patients in Al-Zahra educational hospital, Isfahan, Iran. The intervention group received some training to empower caregivers in family-oriented care in form of an educational counseling program. Data were collected and analyzed using the questionnaires, including demographic, quality of life Short Form-36, and Zarit burden of care questionnaires. Results: The mean ages of caregivers were 48.52 years in the intervention and 45.14 years in the control groups. The results indicated significant differences in mean of quality of life and burden of care in the caregivers of the intervention group after intervention (P<0.01), which was insignificant in the control group. The average burden on the caregivers of both groups was significantly associated with health status, economic status, marital status, the number of children, care hours, care days, and familial relationship of the caregivers with the patients (P<0.01) before intervention. In addition, quality of life of both groups was significantly related to their health status (P<0.01) before intervention. Conclusion: Patient care education reduced the burden of care and improved quality of life of the caregivers of stroke patients. Thus, to reduce the complications of caring for stroke patients, family education should be the priority of nursing and discharging procedures. Keywords: burden of care, family, stroke, quality of lif