Aim. To study the effectiveness of combined therapy (Noliprel, Noliprel forte) and patients’ education, as a complex approach to maximal reduction of total cardiovascular risk. Material and methods. This multi-centre, randomized study, involving 350 therapeutists from 47 Russian cities, included 1050 patients with arterial hypertension (AH), uncontrolled by the previous pharmaceutical therapy. The antihypertensive therapy, AHT (Noliprel, Noliprel forte) was combined with patients’ education in the Health School, aimed at correction of such risk factors (RFs) as dyslipidemia, smoking, and overweight. The control group did not receive any educational intervention. Results. The long-term therapy with Noliprel/Noliprel forte demonstrated high effectiveness and safety of the medication. The prevalence of adequate blood pressure control and treatment response was so high (92,6%) that patients’ education did not increase this parameter. However, in the main group, total risk reduction was larger than in controls, mostly due to decreased smoking prevalence. Conclusion. The study demonstrated high effectiveness and safety of Noliprel/Noliprel forte therapy. Combination of modern AHT and patients’ education resulted in larger reduction of total cardiovascular risk, comparing to pharmaceutical AHT only
