Varicocele is the most common and rological pathology. Varicocele is no. 1 cause of sterility in men. The article illustrates the stages of spermatogenesis that control its hormones and biologically active substances studied in adolescents who have undergone operations for a left-side varicocele. The results obtained indicate the need for and safety of a timely surgery (if there are indications for it) in order to correct varicocele for improved spermatogenic function. Key words: varicocele, antisperm antibodies, inhibin B. (Pediatric Pharmacology. – 2010; 7(4):92-94