A study was conducted in the State of San Luis Potosí, Mexico, to evaluate the biological effectiveness of the insecticide Singular 350 SC (Imidacloprid) for control of sugarcane aphid (Melanaphis sacchari Zehntner) in the sorghum crop (Sorghum bicolor (L.) Moench) Variety: Nikel. A randomized complete block design was implemented, with five treatments and four repetitions; evaluating three doses of Singular 350 SC, a regional control consist in 300 mL ha-1 of Confidor 350 SC and an absolute witness, without insecticides. Two applications were made with a motorized sprayer backpack coupled with two full cone nozzles, being calibrated to apply a total volume of 391 L ha-1. The number of colonies, the yellow aphid infestation and the Abbott efficacy were evaluated at four times. The three doses of Singular 350 SC showed good efficiencies in the control of the number of live colonies and infestation of yellow aphid in sorghum, being greater than 85 % from the first and second evaluation date respectively. The treatments of Singular 350 SC at doses of 250 and 300 mL ha-1 were outstanding, with efficiency percentages higher than 85 % from the first evaluation