Background: there is no consensus among specialists as to determine the best type of sedation/analgesia for endoscopic gastrointestinal procedures.Objective: to describe the use of the combination of ketamine and propofol as inducing agents in patients who underwent therapeutic diagnostic ambulatory colonoscopy at the "Dr. Ernesto Guevara de la Serna" General Teaching Hospital of Las Tunas, between September 2016 and March 2017.Methods: a longitudinal, prospective study was carried out at the aforementioned hospital and during the period herein declared. The sample consisted of 123 patients of the 18 to 70 age group, with ASA 1 and 2 physical statuses, who underwent colonoscopy using ketofol (ketamine 0,4 mg / kg and propofol 1 mg / Kg).Results: there was prevalence of female patients in 58,53 % and of the 50 to 60 age group (35,2 %). The ASA 2 physical status was the most frequent one (55,4 %). In all patients heart rate values were within normal limits. A slight increase was observed in stage II with respect to stage I, as well as a decrease in stages III and IV, and an increase in stage V. Variation in the mean arterial pressure kept stable in stages I and II, with lower values in stages III, IV and V, without decreasing to pathological figures. At none of the studied moments oxygen desaturation occurred. Rapid anesthetic recovery predominated (79,67 %). 78,86 % of the patients did not report pain. Only sleepiness and nausea were identified as complications.Conclusions: most of the patients to whom ketamine and propofol were applied as induction agents showed hemodynamic stability in terms of blood pressure, heart rate and oxygen saturation. Only sleepiness and nausea were identified as complications.</p
