Abstract: the close relatives play important roles in medical, social and psychological ehabilitation of patients with chronic social diseases. In modern medicine, in the biopsychosocial model of rehabilitation received much attention of psycho-social support for patients and their families, aimed at improving the quality of life and social adaptation. As practice shows, parents of children with epilepsy are actively involved at all levels of the biopsychosocial model of rehabilitation of patients with epilepsy, developed and implemented in practice in St. Petersburg V.M. Bekhterev Psychoneurological Research Institute. The aim of this study was to estimate the complex psychological structure of the quality of life of parents of children with epilepsy and the impact of clinical, psychological, and social factors of epilepsy on quality of life of children of their parents. The study showed that epilepsy in children negatively affects the quality of life, psycho-emotional state and social adaptation of their parents. Psychological and psychotherapeutic help parents enable optimizing rehabilitation process of children with epilepsy