ABSTRACT
Introduction: The human prostate gland contains numerous tubular masses of different calibers in its parenchyma. They form the tubuloalveolar prostate glandules, constituting
from numerous prostatic excretory ductules as well as major excretory ducts.
The aim: The study was aimed at 3D visualization of individual microelements of the tubuloalveolar aggregations, localized within the peripheral area.
Materials and methods: To meet the objectives of the study a series of paraffin plane-parallel 4 μm sections has been obtained in the peripheral prostate area. The serial
sections were stained with hematoxylin and eosin. After the analysis of the series of sections, the graphical two-dimensional and plastic 3D reconstructions of the investigated
microobjects have been made sequentially in depth.
Results: Presence of the epithelial creases and invaginations of the wall in the luminal contour of tubuloalveolar aggregations of the prostate has been found. Creases can be
solitary, multiple, or wavy; they can be localized both symmetrically and asymmetrically, with different heights and thicknesses. Intraluminal invaginations, along with the
epithelial crease, contain a stromal muscle component with localized blood loop-shaped microvessel. The creases of the glandular epithelium and intraluminal invaginations
can “overlap” the lumens of the tubuloalveolar aggregations up to 2/3 of the width, making the inner lumen sinuous that influences the laminar flow of the liquid.
Conclusions: Alternation of the considerable enlargement and narrowing of the inner diameter is common for the tubuloalveolar aggregations which can affect the secreta
deposition and movement
