Exposure Assessment of Airborne Acrylamide for Occupationally Exposed Workers by Using an Isotope-Dilution Gas Chromatography Coupled with Mass Spectrometry
Objectives: To develop a highly sensitive analytical method for very low acrylamide (AA) exposure and to conduct an occupational exposure assessment by the developed method. Methods: Seventy-five air samples from four plants were collected and analyzed using an isotope-dilution gas chromatography coupled with mass spectrometry (GC/MS). Results: This isotope-dilution GC MS method is sufficiently sensitive for assessing very low AA level as 4.37 ng m(-3), which is 10- to 7500-fold lower than the current analytical method. Field study showed that most airborne AA was gaseous rather than particulate. The personal exposure levels in workers ranged from 4.37 x 10(-3) m(-3) to 94.90 mu g m(-3) with a mean of 12.08 mu g m(-3). Fifty percent of personal 8 -h time-weighted average (TWA) concentrations in the AA production plant exceeded the threshold limit value of 30 mu g m(-3) set by American Conference of Governmental Industrial Hygienists. Conclusions: The field study indicated that 8-h TWA concentrations in workers varied by two orders of magnitude. The highly sensitive method can be used in future health risk assessment of AA exposure, such as those in fast-food restaurants
