Ideopathic normal pressure hydrocephalus is a common disease causing dementia,
gait disturbance or incontinence. Cerebral ischemia at the periventricular region, aside
from cerebrospinal fluid stagnation, was found to be a major pathophysiologic factor.
Vascular endothelial cell growth factor and placenta growth factor was found to be
elevated in the ventricular cerebrospinal fluid. Material and Methods Correlation was
done on PlGF and VEGF with xenon-computed tomography study and albumin level
or age of the patients. Results PlGF and VEGF are linearly corellated. Excluding age
factor, ventricular PlGF was related to frontal part periventricular cerebral blood flow,
yet not with ventricular albumin level. Ventricular albumin level was inversely related
to the clinical good outcome after shunting (8 l vs 21μg/d). Conclusion Ongoing
periventricular ischemia is one of the major factors in pathogenesis of INPH and
ventricular PlGF can reflect that. However, stagnation of the cerebrospinal fluid
outflow is probably more important factor
