This paper describes a holistic approach to comfort and greenhouse gas emissions in mixed mode offices. It is based on parametric studies for a typical cellular office in the Mediterranean climate of Athens, Greece, using building simulation.Considered parameters are the influence of different building design, varying occupant behaviour and internal heat loads, as well as of an exceptionally hot summer. Additionally, the performance of a cooling strategy following the comfort limits according to the EN 15251 adaptive model is compared with the common fixed cooling set point 22°C.The performance of mixed mode offices is evaluated regarding thermal comfort, daylight autonomy and related greenhouse gas emissions. Results indicate strategies to improve sustainability in mixed mode offices in Athens, by balancing the influencing parameters.<br /