Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
Abstract
THESIS 8060Cancer is the second leading cause of death in the developed world after cardiovascular disease,
with almost 25 million people living with cancer worldwide. The three main therapeutic approaches
for the treatment of cancer involve one or more of the following, surgical removal, radiotherapy or
chemotherapy. While effective against certain cancers, these therapies often have limited success.
Therefore the development of novel and potent immunotherapies may provide more effective means of
controlling malignant disease. Immunotherapeutic approaches are being developed as alternative or
adjuvant therapies and clinical studies have shown that the manipulation of the immune system can
modify tumour progression