The Standard Model of particle physics and the theory of General Relativity
(GR) currently provide a good description of almost all phenomena of particle
physics and gravitation that have received controlled experimental tests.
However, the Standard Model contains many a priori variable parameters whose
values, and whose apparent (near-)constancy, have yet to receive a convincing
theoretical explanation. At the same time, GR may now require to be extended or
altered at the largest length scales, to account for the recent apparent
accelerated cosmological expansion. In this introductory review I present
theoretical aspects of the search for explanations of the values and possible
variations of fundamental ``constants'', focusing on the possibility of
unification of interactions. I also relate cosmological variations to
modifications of gravity both locally and cosmologically.Comment: 17 pages pdflatex, proceedings of introductory lecture for ACFC
Seminar, Bad Honnef 2007, to be published in EPJ Special Topic