Synthesis, double Michael-reaction and antimicrobial activity of cross-conjugated enyone

Abstract

Synthesis of the enyones 6(a-c) has been carried out by catalyzing the reactions with CeCl3. Phase transfer catalyzed double Michael addition reactions of the enyone 6a have also been investigated. The bisannulation could be enforced through the agency of the Lindlar's catalyst. The syntheses of a substituted cyclohexenone 11 and a spiro trione 13 are also described. In addition, antimicrobial activity of all the enyones 6 and the bisbenzalacetone 14 have been reported