Stress enhanced calcium kinetics in a neuron

Abstract

Accurate modeling of the mechanobiological response of a Traumatic Brain Injury is beneficial toward its effective clinical examination, treatment and prevention. Here, we present a stress history-dependent non-spatial kinetic model to predict the microscale phenomena of secondary insults due to accumulation of excess calcium ions (Ca) induced by the macroscale primary injuries. The model is able to capture the experimentally observed increase and subsequent partial recovery of intracellular Ca concentration in response to various types of mechanical impulses. We further establish the accuracy of the model by comparing our predictions with key experimental observations