Morsali, Laleh

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    داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ و ﺧﺪﻣﺎت ﺑﻬﺪاﺷﺘﻲ درﻣﺎﻧﻲ ﻛﺮﻣﺎن  ﻋﻠﻮم داروﻳﻲ داﻧﺸﻜﺪه داروﺳﺎزي و    ﻧﺎﻣﻪ دﻛﺘﺮاي ﻋﻤﻮﻣﻲ داروﺳﺎزيﭘﺎﻳﺎن    ﻋﻨﻮان:-H4-ﺗﺘﺮاﻫﻴﺪرو - 8،7،6،5- آرﻳﻞ-4-اﻛﺴﻮ-5- آﻣﻴﻨﻮ -2-  اﺗﻴﻞ ﻣﺸﺘﻘﺎت ﺳﻨﺘﺰ ﺑﺎﻟﻘﻮه ﺧﻮاص ﺑﺎ ﺟﺰﺋﻲ ﺳﻪ ﻫﺎي واﻛﻨﺶ از اﺳﺘﻔﺎده ﺑﺎ ﻛﺮﺑﻮﻛﺴﻴﻼت- 3-ﻛﺮوﻣﻦ  ﺗﺸﻨﺠﻲ ﺿﺪ      ﺗﻮﺳﻂ:  ﻻﻟﻪ ﻣﺮﺳﻠﻲ     اﺳﺎﺗﻴﺪ راﻫﻨﻤﺎ:  ﻲﭘﻮرﺷﺠﺎﻋدﻛﺘﺮ ﻳﻌﻘﻮب   دﻛﺘﺮ ﻋﺒﺪاﻟﺮﺿﺎ ﺣﺴﻦ زاده        0701 ﻧﺎﻣﻪ: ﻳﺎنﭘﺎﺷﻤﺎره                                                                   79 زﻣﺴﺘﺎن  Kerman University of Medical Sciences Faculty of Pharmacy  Pharm. D Degree      Title: Synthesis of some ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H- chromene-3-carboxylate derivatives via a three component reaction as potential anti-seizure agents.   By: Laleh Morsali  Supervisors: Dr. Yaghoub Pourshojaei Dr. Abdolreza Hasanzadeh   winter 2019                                                               Thesis NO: 1070   ﺧﻼﺻﻪ ﻓﺎرﺳﻲﻛﺮﺑﻮﻛﺴﻴﻼت ﺑﺎ -3-ﻛﺮوﻣﻦ- H4- ﺗﺘﺮاﻫﻴﺪرو - 5،6،7،8-آرﻳﻞ- 4-اﻛﺴﻮ-5- آﻣﻴﻨﻮ -2-ﺳﻨﺘﺰ ﻣﺸﺘﻘﺎت اﺗﻴﻞ  ﻫﺪف:   اﺳﺘﻔﺎده از واﻛﻨﺶ ﻫﺎي ﺳﻪ ﺟﺰﺋﻲ ﺑﺎ ﺧﻮاص ﺑﺎﻟﻘﻮه ﺿﺪ ﺗﺸﻨﺠﻲﻣﻨﺎﺳﺐ، اﺗﻴﻞ ﺳﻴﺎﻧﻮ اﺳﺘﺎت و  ﺪﻫﺎي آروﻣﺎﺗﻴﻚﻫﺎي ﭼﻨﺪ ﺟﺰﺋﻲ ﺑﻴﻦ آﻟﺪﻫﻴ ﺗﺮﻛﻴﺒﺎت ﻫﺪف ﺗﻮﺳﻂ واﻛﻨﺶ روش:ﻣﻮرد  )RMN C31 ,RMNH1,RI(ﻫﺎي ﻃﻴﻒ ﺳﻨﺠﻲ  ﺳﻴﻜﻠﻮﻫﮕﺰان دﻳﻮن ﺑﺎ ﺑﺎزده ﺧﻮب ﺗﻬﻴﻪ ﺷﺪ و ﺑﺎ روش-3،1  ﺷﻨﺎﺳﺎﻳﻲ و ﺗﺎﺋﻴﺪ ﻗﺮار ﮔﺮﻓﺘﻨﺪ.ﻫﺎي ﭼﻨﺪ  ﻫﺎ ﺑﺎ اﺳﺘﻔﺎده از واﻛﻨﺶ از ﻛﺮوﻣﻦدر ﺗﺤﻘﻴﻖ ﺣﺎﺿﺮ، ﺑﻪ ﺳﻨﺘﺰ ﻣﺸﺘﻘﺎت ﺟﺪﻳﺪ  ﺑﺤﺚ و ﻧﺘﻴﺠﻪ ﮔﻴﺮي:در ﺣﻀﻮر ﻛﺎﺗﺎﻟﻴﺰور ﭘﺘﺎﺳﻴﻢ ﻛﺮﺑﻨﺎت در ﺷﺮاﻳﻂ ﺳﺎزﮔﺎر ﺑﺎ ﻣﺤﻴﻂ زﻳﺴﺖ ﭘﺮداﺧﺘﻪ ﺷﺪه. اﺳﺘﻔﺎده از ﭘﺘﺎﺳﻴﻢ 1ﺟﺰﺋﻲﻫﺎي  ﻛﺮﺑﻨﺎت ﺑﻪ ﻋﻨﻮان ﻳﻚ ﻛﺎﺗﺎﻟﻴﺰور ﺑﺎزي ﺳﺒﺰ و ﺳﺎزﮔﺎر ﺑﺎ ﻣﺤﻴﻂ زﻳﺴﺖ ﺑﻪ ﻋﻨﻮان ﻳﻚ ﻣﺰﻳﺖ ﺑﺮاي واﻛﻨﺶدﻳﮕﺮ از ﻣﺰاﻳﺎي اﻳﻦ واﻛﻨﺶ ﺗﻮﻟﻴﺪ ﻣﺤﺼﻮﻻت ﺑﺎ راﻧﺪﻣﺎن ﺑﺎﻻ در ﻣﺪت زﻣﺎن  آﻳﺪ. ﻳﻜﻲ ﺷﻴﻤﻴﺎﻳﻲ ﺑﻪ ﺣﺴﺎب ﻣﻲ  ﺑﺎﺷﺪ. ﻛﻮﺗﺎه ﻣﻲ  ﻛﺮوﻣﻦ، ﺿﺪ ﺗﺸﻨﺞ - H4واﻛﻨﺶ ﻫﺎي ﺳﻪ ﺟﺰﺋﻲ،ﻛﻠﻤﺎت ﻛﻠﻴﺪي:  tcartsbA-enemorhc -H4-ordyhartet-8,7,6,5-lynehp-4-oxo-5-onima-2 lyhte emos fo sisehtnyS :sevitcejbO .stnega eruzies-itna laitnetop sa noitcaer tnenopmoc eerht a aiv sevitavired etalyxobrac-3 lyra etairporppa na neewteb noitcaer morf deniatbo erew stcudorp detegrat ehT :dohteM ehT .sdleiy tnellecxe ot doog ni enoidenaxeholcyc-3,1 dna etatecaonayc lyhte ,sedyhedla RMN C31 dna ,RMNH1 ,RI-TF yb demrifnoC erew stcudorp levon lla fo serutcurts lacimehc .seipocsortceps                                                             tnenopmoc-itluM-1 Results and Discussion: In this work some novel chromene derivatives successfully synthesized The synthesis was carried out throughout a multicomponent protocol in the presence of potassium carbonate as an effective, green and safe basic catalyst under an eco-friendly procedure. Being environmentally-benign, obtaining products in short reaction times along with high yields could be countered as the some important advantages of this protocol.  Keywords: Three-component reaction; 4H-Chromene; Anti-seizure     

Synthesis of some ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H- chromene-3-carboxylate derivatives via a three component reaction as potential anti-seizure agents

http://eprints.kmu.ac.ir/30936/1/7088.pdf

Synthesis of some ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H- chromene-3-carboxylate derivatives via a three component reaction as potential anti-seizure agents

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