Instability of total hip and knee replacements prevails as major complication. As measurements in patients are afflicted with ethical objections, this work presents a hardware-in-the-loop (HiL) approach that is capable of testing total joint stability under dynamic, reproducible and physiological conditions. An essential aspect represents its validation which includes the development of specific multibody models. In this sense, the HiL test system extends the repertoire of common approaches in orthopedic research by combining the advantages of real implant testing and model-based simulation
