KOŠTANI MORFOGENETSKI PROTEINI I KOLOREKTALNI KARCINOM

Abstract

Rak debelog crijeva po pojavnosti je jedan od najucestalijih zlocudnih oboljenja i najcešci uzrok smrti meu malignim bolestima u svijetu. Neki od cimbenika rizika za nastanak ovoga karcinoma su genetska sklonost te loše životne i prehrambene navike. Koštani morfogenetski proteini (BMPs) su dobili ime po tome što su prvotno izolirani iz kosti, ali pokazuju ucinak i na druga tkiva i organe. Istraživanje provedeno na 10 uzoraka karcinoma debelog crijeva je pokazalo da se karcinom debelog crijeva cešce javlja u muškaraca (70%) i osoba starije životne dobi (od 55 do 74 godine). Najcešci tip tumora je bio adenokarcinom, umjereno diferenciranog stadija B ili C prema Dukesovom sustavu. Sigmoidni kolon i rektum su bile najcešce lokalizacije tumora. Izražaj BMP4 i BMP7 je prisutan u svim uzorcima karcinoma debelog crijeva. Ekspresija BMP4 je ujednacena u svim uzorcima, dok ekspresija BMP7 se smanjuje s napredovanjem bolesti. Ovi rezultati pokazuju da bi se BMPs mogli koristiti kao moguci pokazatelji malignosti bolesti.Colorectal cancer is the one of the most commonly cancers in the world and one of the leading causes of cancer-related mortality. Some of the risk factors for developing of colorectal cancer are genetic suspectibility, life style and dietery habits. Bone morphogenetic proteins (BMPs) are named because they are primarely isolated from bone. They exert their function beyond the bone on the other tissues and organs. The analysis of 10 samples of colorectal cancer revealed that colorectal cancer is occured more frequently in male (70%) and in older individuals (from 55 to 74 yrs). The most common histological type of carcinoma was adenocarcinoma, moderate differentiated Dukes stage B or C. Sigmoid colon and rectum was the most common localization of colorectal cancer. According to BMP expression, BMP4 and BMP7 were expressed in all examined samples. BMP4 showed unchanging expression in all samples whereas BMP7 expression decerased during the progression of the disease. These results suggested that BMPs can be used as possible markers for malignity