Aeschbacher

Anderson

Burdock

Claxton

Costello

Cowan

Cramer

Curvall

Damani

Durrer

EC (European Commission)

Florin

Fujita

Gillam

Gorrod

Grubbs

Hashizume

Hawksworth

Haworth

IOFI (International Organization of the Flavor Industry)

Izmerov

Jakoby

JECFA (Joint FAO/WHO Expert Committee on Food Additives)

Kaden

Kaiser

King

Klaassen

LaVoie

Laws

Lehninger

Martinez

McGee Laboratories Inc.

McKee

McKennis

Miller

Moran

Myers

Nijssen

Novello

Ochiai

Posner

Posternak

Reddy

Reigh

Ruangyuttikarn

Sasagawa

SCF (Scientific Committee for Food)

Scharping CE, Duke CC, Holder GM and Larden D

Schriewer

Shigenaga

Skiles

Skordos

Smith

Smyth

Spanjers

Steiner

Stoner

Szybalski

Tada

Tanaka

Taylor

Thornton‐Manning

Vance

Wang

Whittaker

Williams

Yost

Zeiger

Zimmermann

EFSA Journal

null null

Crossref

Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur‐containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 24 flavouring substances in the Flavouring Group Evaluation 24, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. This revision was made required owing to the inclusion of the assessment of new toxicity data on one supporting substance, 2-acetylpyrrole [FL-no: 14.047], to support the re-evaluation of one candidate substance, 2-acetyl-5-methylpyrrole [FL-no: 14.085]. Nine of the original 33 candidate substances [FL-no: 13.100, 14.002, 14.023, 14.094, 14.107, 14.138, 14.145, 14.163 and 14.169], for which additional data were requested, are no longer supported by Industry for use as flavouring substances in Europe and will therefore not be considered any further. None of the 24 substances were considered to have genotoxic potential. These candidate substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that the 24 substances [FL-no: 14.085, 14.088, 14.089, 14.092, 14.093, 14.103, 14.104, 14.105, 14.106, 14.110, 14.115, 14.116, 14.117, 14.118, 14.120, 14.124, 14.125, 14.131, 14.134, 14.135, 14.136, 14.140, 14.143 and 14.150] do not give rise to safety concern at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the materials of commerce have been provided for all 24 candidate substances.<br/

Online Research Database In Technology

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2)

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present opinion concerns a group of 26 sulphur-containing heterocyclic compounds evaluated by the JECFA at the 59th meeting in 2008. This revision is made due to the inclusion of one additional substance, 5-methyl-2-thiophenecarbaldehyde [FL-no: 15.004], cleared for genotoxicity concern in FGE.224. Additionally, new toxicity data have become available for 5,6-dihydro-2,4,6-tris(2-methylpropyl)-4H-1,3,5-dithiazine [FL-no: 15.113]. Since publication of FGE.76, one substance, thiazole [FL-no: 15.028], is no longer supported by Industry for use as a flavouring substance in Europe and will therefore not be considered any further. The substances were evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel agrees with the application of the Procedure as performed by the JECFA for 21, [FL-no: 15.001, 15.002, 15.004, 15.008, 15.011, 15.013, 15.014, 15.015, 15.016, 15.017, 15.019, 15.020, 15.021, 15.022, 15.026, 15.027, 15.033, 15.035, 15.109, 15.113 and 16.027], of the 26 substances considered in this FGE and agrees with the JECFA conclusion, “No safety concern at estimated levels of intake as flavouring substances” based on the MSDI approach. For five substances [FL-no: 15.005, 15.018, 15.029, 15.030 and 15.032], the Panel could not conclude on their safety when used as flavouring substances, as these substances could not be evaluated because of concern with respect to genotoxicity. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 26 substances, the information is adequate.<br/

EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1)

Gontard, Nathalie

HAL-CIRAD

Scientific Opinion on Flavouring Group Evaluation 207 (FGE.207): Consideration of genotoxic potential for one branched‐chain aliphatic acyclic α,β‐unsaturated 2‐alkylated aldehyde with additional double‐bonds, from subgroup 1.1.2 of FGE.19 and four alicyclic aldehydes with the α,β‐unsaturation in a side‐chain, from subgroup 2.1 of FGE.19, which are considered to be covered by the one substance of subgroup 1.1.2, by EFSA

Scientific opinion on Flavouring Group Evaluation 24, Revision 2 (FGE.24Rev2): Pyridine, pyrrole, indole and quinoline derivatives from chemical group 28

HAL Descartes

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of one flavouring substance, 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931], from subgroup 1.1.2 of FGE.19, which is considered to be representative for four substances, 12-beta-santalen-14-ol [FL-no: 02.216], 12-alpha-santalen-14-ol [FL-no: 02.217], santalyl acetate [FL-no: 09.034] and santalyl phenylacetate [FL-no: 09.712], from subgroup 2.1 of FGE.19. The Flavour Industry has provided genotoxicity studies for the representative substance 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931] and these data are considered by EFSA to be representative for the four substances [FL-no: 02.216, 02.217, 09.034 and 09.712]. Based on the new data, the Panel concluded that 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931] from FGE.19 subgroup 1.1.2 does not give rise to concern with respect to genotoxicity and can accordingly be evaluated using the Procedure. This conclusion can also be applied to the four substances 12-beta-santalen-14-ol [FL-no: 02.216], 12-alpha-santalen-14-ol [FL-no: 02.217], santalyl acetate [FL-no: 09.034] and santalyl phenylacetate [FL-no: 09.712] from FGE.19 subgroup 2.1 for which 2,6-dimethyl-2,5,7-octatriene-1-ol acetate [FL-no: 09.931] is representative.© European Food Safety Authority, 2013<br/