Audouze

Camon

Christian Kalhauge

Croft

Daniel Edsgärd

Davis

Hamosh

Judson

Kanehisa

Karine Audouze

Knox

Kuhn

Olga Rigina

Olivier Taboureau

Ramneek Gupta

Rappaport

Safran

Ulrik Plesner Jacobsen

Summary: Humans are exposed to diverse hazardous chemicals daily. Although an exposure to these chemicals is suspected to have adverse effects on human health, mechanistic insights into how they interact with the human body are still limited. Therefore, acquisition of curated data and development of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical–protein interactions have been enriched with a quality-scored human protein–protein interaction network, a protein–protein association network and a chemical–chemical interaction network, thus allowing the study of environmental chemicals through formation of protein complexes and phenotypic outcomes enrichment. Availability: HExpoChem is available at http://www.cbs.dtu.dk/services/HExpoChem-1.0/. Contact: karine@cbs.dtu.dk Supplementary information: Supplementary data are available at Bioinformatics online

Taboureau, Olivier

Jacobsen, Ulrik Plesner

Kalhauge, Christian Gram

Edsgard, Stefan Daniel

Rigina, Olga

Gupta, Ramneek

Audouze, Karine Marie Laure

Online Research Database In Technology

HExpoChem: a systems biology resource to explore human exposure to chemicals

Abstract
               Summary: Humans are exposed to diverse hazardous chemicals daily. Although an exposure to these chemicals is suspected to have adverse effects on human health, mechanistic insights into how they interact with the human body are still limited. Therefore, acquisition of curated data and development of computational biology approaches are needed to assess the health risks of chemical exposure. Here we present HExpoChem, a tool based on environmental chemicals and their bioactivities on human proteins with the objective of aiding the qualitative exploration of human exposure to chemicals. The chemical–protein interactions have been enriched with a quality-scored human protein–protein interaction network, a protein–protein association network and a chemical–chemical interaction network, thus allowing the study of environmental chemicals through formation of protein complexes and phenotypic outcomes enrichment.
               Availability: HExpoChem is available at http://www.cbs.dtu.dk/services/HExpoChem-1.0/.
               Contact:  karine@cbs.dtu.dk
               Supplementary information:  Supplementary data are available at Bioinformatics online.</jats:p

Crossref

Bioinformatics

HExpoChem: a systems biology resource to explore human exposure to chemicals

Abstract

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Online Research Database In Technology

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