Pengaruh Pemberian Ekstrak Buah Naga Putih
(Hylocereus undatus) terhadap Kerusakan
Histologis Sel Ginjal Mencit (Mus musculus) yang
Diinduksi Parasetamol
Background: White dragon fruit (Hylocereus undatus) contains antioxidant
substances in the form of vitamin A, C, E, and polyphenol that are reported to be
nephroprotective. This study was aimed to verify the effect of white dragon fruit
extract and its increasing doses toward paracetamol-induced damage of renal cell of
mouse (Mus musculus).
Methods: This study was a Randomized Controlled Trial in design. Samples were
twenty eight Swiss webster type mice divided into 4 groups randomly, being seven
mice in each group. Aquades were administered to mice in control group (KK) and
the first group (KP1), while white dragon fruit extract were administered to the
second group (KP2) and the third group (KP3) with the dose of 70 mg/20 g BB
weight and 140 ml/20 g weight for 14 days, respectively. Paracetamol were
administered to KP1, KP2, KP3, with dose 5.07 mg/ 20 g weight on day 12th, 13th
and 14th. On day 15th, mice were sacrificed with neck dislocation. Renal cell slides
were made and stained by HE. Renal histological is analysed and scored base on
quantification of renal histological damage. Data were analyzed by One-Way ANOVA
test and Post Hoc test.
Results: One-Way ANOVA showed that there was a significant difference between
groups. Result of LSD method showed that there were significant of differences
between KK-KP1, KK-KP2, KP1-KP2, KP1-KP3 and KP2-KP3groups, respectively; while
no significant different was found between KK-KP3.
Conclusion: The administration of white dragon fruit extract might prevent the
mice renal cell damage. The increasing doses of white dragon fruit extract induce
protection effect towards the renal cell damage of mice induced by paracetamol
Key words : white dragon fruit extract, paracetamol, renal cell damage
