Brochado, Ana Rita

A holistic view of the cell is fundamental for gaining insights into genotype to phenotype relationships. Systems Biology is a discipline within Biology, which uses such holistic approach by focusing on the development and application of tools for studying the structure and dynamics of cellular processes. Metabolism is an extensively studied and characterised subcellular system, for which several modeling approaches have been proposed over the last 20 years. Nowadays,stoichiometric modeling of metabolism is done at the genome scale and it has diverse applications, many of them for helping at better characterizing genotype to phenotype relationships. Metabolic Engineering is one of the fields in which the complete understanding of such relationship would have a striking impact, since phenotype prediction based on genotype is fundamental for rationally engineering metabolic networks. This chapter aims at providing the reader with relevant state-of-the-art information concerning Systems Biology, Genome-ScaleMetabolic Modeling and Metabolic Engineering. Particular attention is given to the yeastSaccharomyces cerevisiae, the eukaryotic model organism used thought the thesis

Online Research Database In Technology

Investigating genotype-phenotype relationships in Saccharomyces cerevisiae metabolic network through stoichiometric modeling

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Investigating genotype-phenotype relationships in Saccharomyces cerevisiae metabolic network through stoichiometric modeling

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Online Research Database In Technology