Josip Juraj Strossmayer University of Osijek. Faculty of Medicine.
Abstract
Cilj istraživanja: Ispitati kvalitetu života bolesnika na hemodijalizi i korelaciju između laboratorijskih pokazatelja upale i pojave kroničnog umora Nacrt studije: Istraživanje je presječna studija. Ispitanici i metode: Istraživanje je provedeno na 110 bolesnika sa završnim stadijem kronične bubrežne bolesti na kroničnom programu hemodijalize. Subjektivni osjećaj zdravlja ispitan je pomoću standardiziranog upitnika zdravstvenog statusa SF-36. Upitnikom se ispituju tjelesne, duševne ili društvene posljedice nastale zbog ograničenog zdravlja. Dobiveni rezultati ankete uspoređeni su s laboratorijskim pokazateljima upale. Rezultati: Najviša ocjena kvalitete života dana je socijalnom funkcioniranju i mentalnom zdravlju, a najveće nezadovoljstvo predstavlja ograničenje aktivnosti zbog tjelesnog zdravlja. Ukupna ocjena tjelesne aktivnosti značajno je niža kod ispitanika s Glasgow prognostičkim indeksom 2, u odnosu na ispitanike s Glasgow prognostičkim indeksom 0 ili 1. Laboratorijski pokazatelji upale koji pozitivno koreliraju s česticama kvalitete života (SF-36) su koncentracija albumina u serumu, vrijednosti trombocita, koncentracija uree u serumu prije i nakon hemodijalize. Koncentracija CRP-a, vrijednost leukocita, vrijednost RDW-a, iznos URR-a te duljina liječenja hemodijalizom negativno koreliraju s česticama kvalitete života (SF-36). Povezanost koncentracije hemoglobina s kroničnim umorom i kvalitetom života bolesnika na hemodijalizi nije dokazana. Zaključak: Kronični umor značajan je problem bolesnika za završnim stadijem kronične bubrežne bolesti i zahvaća brojne aspekte života.Objectives. The aim of this study was to examine the quality of life in patients on hemodialysis and correlation between laboratory indicators of inflammation and chronic fatigue. Study design. The study is structured as a cross-section study. Participants and methods. The study was conducted on 110 patients with end stage chronic renal disease in chronic hemodialysis program. The subjective feeling of health was tested using a standard SF-36 health status questionnaire. The questionnaire examines physical, mental or social consequences caused by ill health. The results of the survey were compared to laboratory indicators of inflammation. Results. The highest quality of life is attributed to social functioning and mental health, and the greatest dissatisfaction is the limitation of activity because of the physical health. The overall body activity rating is significantly lower for those with Glasgow Prognostic Score 2 compared to those with Glasgow Prognostic Score 0 or 1. Laboratory indicators of inflammation which correlate positively with domains of quality of life (SF-36) are serum albumin concentrations, platelet counts, and urea concentration in serum before and after hemodialysis. CRP concentration, white blood cell count, RDW values, URR and hemodialysis duration all correlate negatively with domains of quality of life (SF-36). The correlation of hemoglobin concentrations with chronic fatigue and the quality of life of patients treated by hemodialysis has not been demonstrated. Conclusion. Chronic fatigue is a significant problem for patients with end stage chronic renal disease and it affects many aspects of patients’ life
