University of Zagreb. Faculty of Food Technology and Biotechnology.
Abstract
Cilj ovog istraživanja bio je karakterizirati indukciju mehanizama urođene imunosti na viruse mumpsa različitog stupnja atenuacije. Kao virusni faktori koji mogu modulirati te mehanizme ispitane su defektne intereferirajuće čestice prisutne u virusnoj suspenziji te ekspresija virusnog proteina V. Proizašla saznanja primijenjena su za ciljanu atenuaciju divljeg soja virusa mumpsa kao modela za razvoj novog atenuiranog cjepiva.The aim of this study was to characterize the innate immune responses to mumps viruses of different attenuation level. Defective interfering particles present in the viral suspensions and expression of the viral V protein were examined as viral factors critical for modulation of these responses. The gained knowledge was further applied for targeted attenuation of a wild-type mumps virus as a model for development of a new attenuated vaccine
