MICROORGANISMS ISOLATED FROM BIOLOGICAL SAMPLES OF CHILDEN TREATED IN THE DEPARTMENT OF INTENSIVE CARE OF CHILDREN FOR CHILDREN'S DISEASES CHC SPLIT IN THE PERIOD BETWEEN 2013 AND 2015

Abstract

CILJ ISTRAŽIVANJA: Cilj ovog istraživanja bio je analizirati demografska obilježja djece liječene u Zavodu za intenzivnu pedijatriju s postintenzivnom skrbi Klinike za dječje bolesti KBC-a Split, epidemiologiju infekcija i njihovu povezanost s korištenjem medicinskih uređaja. Nadalje htjeli smo istražiti pojavnost pojedinih mikrobioloških uzročnika, ispitati njihovu osjetljivost na antibiotike i nalaze povezati s demografskim obilježjima djece. ISPITANICI I METODE: Retrospektivno je analizirana medicinska dokumentacija djece liječene u Zavodu za intenzivnu pedijatriju s postintenzivnom skrbi KBC-a Split. Za potrebe istraživanja korišteni su također i mikrobiološki nalazi Kliničkog zavoda za mikrobiologiju i parazitologiju KBC-a Split. REZULTATI I ZAKLJUČAK: Novorođenčad su bili najrizičnija dobna skupina za razvoj infekcija i imali su najviše bakterijemija. Među kulturama krvi, urina i aspirata traheje bilo je najviše izoliranih gram negativnih bakterija, dok su gljivice izolirane u manjem postotku od očekivanog. Analizom mikrobiološke osjetljivosti najotpornijih izolata u djece liječene u JILD-u dokazana je visoka rezistencija P. aeruginosa na karbapeneme. Uporaba različitih invazivnih postupaka koji se primjenjuju u Zavodu za intenzivnu pedijatriju s postintenzivnom skrbi povezana je s razvojem infekcije.OBJECTIVE: To analyze demographic imprint of children treated in Pediatric intensive care unit (PICU) of Split University hospital, epidemiology of infections and its connection to the usage of medical equipment. Furthermore, objective was to determine incidence of certain microbiological isolates, test its sensitivity on antibiotics and answer the question if these indicators vary depending on demographic imprints of children. PATIENTS AND METHODS: For the intent of obtaining the data, medical documentation created in the PICU of Split University Hospital was analyzed retrospectively. Equally, for the purpose of research, microbiological findings were adopted from Microbiological department of Split Univerity Hospital. RESULTS AND CONCLUSION: Newborns had the highest risk for developing infections and had the most cases of bacteremia. Within blood culture, urine culture and tracheal wash gram negative bacteria were the most common isolates, while the fungus were isolated in lower rate than expected. Once we analyzed microbiological sensitivity of the most resistant isolates within children treated in PICU of Split University Hospital, we have fonud the worrisome high resistence of P. aeruginosa for carbapenems. The research shown that the usage of various invasive procedures which are applied at PICU were associated with infection development