Jonsson, Gunnar Eigil

Jørgensen, Sten Bay

Prado Rubio, Oscar Andres

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Dec 19, 2017Model based design and operation of a membrane bioreactor for lactic acid productionPrado Rubio, Oscar Andres; Jørgensen, Sten Bay; Jonsson, Gunnar EigilPublication date:2011Document VersionPublisher's PDF, also known as Version of recordLink back to DTU OrbitCitation (APA):Prado Rubio, O. A., Jørgensen, S. B., & Jonsson, G. E. (2011). Model based design and operation of amembrane bioreactor for lactic acid production. Abstract from 8th European Congress of Chemical Engineering,Berlin, Germany.MODEL BASED DESIGN AND OPERATION OF A MEMBRANE BIOREACTOR FOR LACTIC ACID PRODUCTION  Oscar Andrés Prado-Rubio, Sten Bay Jørgensen and Gunnar Jonsson  Department of Chemical and Biochemical Engineering Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark   Keywords: Lactic acid production, Reverse Electro-Enhanced Dialysis. pH controlled fermentation  Theme: Bioprocess engineering, modelling, measurement and control  Due to the increasing lactic acid demand, as primary feed-stock for Polylactic acid production, diverse technologies have been investigated in order to reduce production cost. Thereby polylactic acid production can become economically feasible and substitute its petrochemical based competitors. One main constraint during lactic acid fermentation is product inhibition. Therefore, productivity and yield can be increased by the continuous removal of the biotoxic lactate from the fermentation broth. Membrane bioreactors have shown satisfactory performance in bioseparations, thus they have been increasingly investigated for lactic acid production. Recently, an integrated bioreactor and electrically driven membrane separation process (Reverse Electro-Enhanced Dialysis - REED) has been proposed as a method for in situ continuous lactate removal of the fermentation broth (Rype, 2003). During the system operation, lactate is exchanged by hydroxide ions my means of anion exchange membranes combined with periodically varying electrical current to reduce fouling. Such a membrane system allows reducing lactate inhibitory effect and simultaneously assisting the pH control in the bioreactor.   The integrated system is investigated based upon previously developed mathematical models (Boonmee et al. 2003, Prado-Rubio et al., 2009; 2010). Due to the dynamic behavior associated with the individual units plus their interaction, the design and operability of the integrated system constitutes a key issue. The purpose of this contribution is to discuss these challenges and propose a methodology for investigating the integrated system design and operation. The operability of the membrane bioreactor is highlighted through the continuous production of lactic acid. A control structure is designed and its performance evaluated. As a result, the membrane and reactor units interactions are exploited to substantially increase the lactate productivity and substrate utilization compared to a conventional fermentation. At the same time the pH control in the fermenter is facilitated reducing the base consumption. From the preliminary results, it is expected that the implementation of more advanced control structures and controllers can increase even further the process performance.  References  Boonmee, M.; Leksawasdi, N.; Bridge, W. and Rogers, P. (2003). Batch and Continuous Culture of Lactococcus lactis NZ133: Experimental Data and Model Development. Biochemical Engineering Journal, 14, 127-135. Prado-Rubio, O.A.; Jørgensen, S.B. and Jonsson, G. (2009). Tool for Optimizing the Design and Operation of Reverse Electro-Enhanced Dialysis of Monoprotic Carboxylic Acids. In proceedings: 10th International Symposium on Process Systems Engineering. Prado-Rubio, O.A.; Jørgensen, S.B. and Jonsson, G. (2010). Control System Development for Integrated Bioreactor and Membrane Separation Process. In proceedings: 20th European Symposium on Computer-Aided Engineering. Rype, J. (2003). Modelling of Electrically Driven Processes. Ph.D. thesis, Technical University of Denmark.   

Model based design and operation of a membrane bioreactor for lactic acid production

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Model based design and operation of a membrane bioreactor for lactic acid production

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