Catsch, A.

Seidel, A.

Volf, V.

English

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INT. J. RADIAT. BIOL., 1971, VaL. 19, NO. 4, 399-400Effectiveness of Zn-DTPA in removal of plutoniumfrom ratsA. SEIDEL, Y. YOLF and A. CATSCRInstitut für Strahlenbiologie, Kernforschungszentrum,75 Karlsruhe 1, Postfach 3640, Germany(Received 16 January 1971; accepted 22 January 1971)The use of the Zn-chelate of diethylenetriaminepentaacetate (DTPA)instead of Ca-DTPA for removal of internaIly-deposited radionuclides has beensuggested (Catsch 1968, Catsch, Lö and Chambault 1964). This recom-mendation is based on the fact that Zn-DTPA has a markedly lower toxicitythan Ca-DTPA (Catsch 1964, Catsch and Wedelstaedt 1960, Seide11970, Smith1970, Weber 1969), but is only slightly less effective in mobilizing 91y andI44Ce from the body (Catsch et al. 1964). Meanwhile, both chelates were foundto be equally effective in removing 147pm (Smith 1970), whereas the influenceCa-DTPA on the excretion of 239PU seems to surpass that of the Zn-chelate(Smith 1966). In the latter study, chelate treatment was initiated 1 hour afterinjectioh of 239PU; the main objective of Zn-DTPA, however, is the delayedtreatment situation (Catsch 1968). In view of the great importance of 239PU, areinvestigation was advisable.Fernale albino rats averaging 190 g in weight were injected intravenouslywith 0·2 fLCi monomeric 239pu(IY) (0,25 ml., pR 8,5). Monomeric Pu wasprepared according to Taylor (personal communication) by diluting the stocksolution of PU(N03)2 with sodium citrate and filtration through millipore filter(pore diameter 25 nm) before injection. Na3[Ca-DTPA] and Na3[Zn-DTPA],respectively, were injected intraperitoneally on the 6th, 8th and 11th day; thedosage equalled 1 mmol x kg-I x d-I (2 ml., pR 7·4). The o-activity of tissuesamples was assayed by liquid scintillation counting (Seidel and Volf, in press).5456IControl Control Ca-DTPA Zn-DTPA(0-9 per cent NaCI)6th day 13th day 13th day 13th dayLiver 14-6 ±0'88 7-15 ±0'71 1'44 ±0'07 1-64 ±0'09Spleen 0-24 ±0'02 0·32 ±0'02 0-16 ±0'01 0·18 ±0,01Kidneys 1-04 ±0'04 0'74 ±0'05 0'45 ±0-04 0·36 ±0-02Lung 0·14 z OOt 0-12 ±0'01 0'047 ± 0'003 0·054 ±0'005Thyroid 0-22 ±0·003 0·016 ±0'0005 0-009 ± 0·001 0·008 ±0'001Adrenals 0·012 ± 0'001 0'013 ± 0·001 0-006 ± 0-001 0·0062 ± 0-0003I Ovaries 0·017 ± 0'001 0·016 ±0'002 0'010 ± 0-001 0-009 ±0'001Skeleton 62·0 ± 1'09 56'5 ±0'54 41'5 ±2'20 40·9 ±0'79239Pu-content of the organs (percentage of 239Pu_dose).Means ± S.E. n = number of animals.400 CorrespondenceAs can be seen from the table, both chelates show virtually equal efficacyin lowering the 239Pu-content of the organs. This is in keeping with recentresults obtained by Smith (personal communication) with 238PU. The favour-able result of our study prompted us to start a more detailed investigation, whichwill be concerned with the action of Zn-DTPA on monomeric and polymeric239PU as influenced by treatment schedule.F,-EFERE~~CESCATSCH, A., 1964, Arch. exp. Path. Pharmak., 246, 316; 1968, Dekorporierung radioaktiverund stabiler Metallionen (München: K. Thiemig).CATSCH, A., L~, D. KH., and CHAMBAULT, D., 1964, Int. J. Radiat. Biol., 8, 35.CATSCH, A., and WEDELSTAEDT, E. VON, 1960, Experientia, 21, 210.SEIDEL, A., 1970, Strahlentherapie, 139, 603.SEIDEL, A., and VOLF, V. (in the press).SMITH, V. H., 1966, BNWL-280, 81; 1970, BNWL-1050, part 1,5.3.WEBER, K. M., 1969, Z. ges. exp, Med., 150,354.

Effectiveness of Zn-DTPA in removal of plutonium from rats

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Effectiveness of Zn-DTPA in removal of plutonium from rats

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