University of Zagreb. Faculty of Chemical Engineering and Technology.
Abstract
U ovom radu proučavana je reakcija aldolne adicije dihidroksiacetona (DHA) na N-Cbz-3-aminopropanal katalizirana D-fruktoza-6-fosfat aldolazom A129G, čiji produkt je prekursor za sintezu D-fagomina, prirodnog iminošećera izvanrednih bioloških svojstava te je iz tog razloga reakcija od interesa. Za ovu reakciju napravljeni su modeli u kotlastom, cijevnom i protočno kotlastom reaktoru. Pomoću tih modela predviđene su konverzije, pri različitim procesnim uvjetima u reaktorima. Kao najbolji reaktor za provedbu ove reakcije se pokazao kotlasti reaktor.The reaction of aldol addition of dihydroxyacetone (DHA) on the N-Cbz-3-D-aminopropanal catalyzed by fructose-6-phosphate aldolase A129G, which reaction product is precursor for the synthesis of D-fagomine, natural iminosugar with remarkable biological properties is investigated in this paper. Because of the very interesting product the reaction is of high interest. The reaction is modelled in batch, plug flow and continuous stirred tank reactor. The conversion of reactants is predicted using the models at various process conditions. The best reactor for this reaction is batch reactor
