Hvilsted, Søren

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Dec 18, 2017Poly(-caprolactone) - The Viable Scaffold for Construction of IntriguingBiomacromoleculesHvilsted, SørenPublication date:2011Link back to DTU OrbitCitation (APA):Hvilsted, S. (2011). Poly(-caprolactone) - The Viable Scaffold for Construction of Intriguing Biomacromolecules.Abstract from Europolymer conference 2011 : EUPOC 2011, Gargnano, Lago di  Garda, .Poly(ε-caprolactone) – the viable scaffold forconstruction of intriguing biomacromoleculesSøren HvilstedDanish Polymer CentreDepartment of Chemical and Biochemical EngineeringTechnical University of Denmark, Building 227DK-2800 Kgs. Lyngby, Denmarksh@kt.dtu.dkThe classical medical material workhorse, poly(ε-caprolactone) (PCL), has been employed as a viable scaffold for designof several novel materials with intriguing, potentially therapeutical and biological properties. Living ROP strategies haveafforded telechelic PCLs that can be utilized in either ATRP to make amphiphilic block copolymers or various “click”reactions resulting in multi-component materials. Three different examples will be elaborated.In the first case gold nanoparticles protected with a polymeric shell may combine ablative therapy and site-specific drugdelivery in bladder cancer therapy. This may be accomplished by tailoring the surface properties and the size of the goldclusters. The former may be addressed by devising polymeric ligands with desirable features and functional groups. Thusthe preparation of the PCL-b-PAA corona will be outlined. The synthesis of the effective macro-ligand that allowspreparation of the stable gold cluster and provides nanoenvironment for hydrophobic anticancer drugs and mucoadhesiveanchoring on mucous membranes is one of the objectives of this study.The second approach is the ligation of biologically active moieties to the termini of a hydrophobic polymeric chain (PCL)to afford the amphiphilic linear-dendritic macromolecule that comprises rod-like, coil-like, and dendritic fragments.Furthermore this may self-assemble in solid state as well as in aqueous solution. The facile route to linear-dendriticcholesteryl-b-PCL-b-(L-lysine)G2 by thiol-ene and azide-alkyne “click” reactions will be elucidated. Here the drivingmotivation was to contrive a robust, facile, and effective synthetic strategy.Finally, the preparation of PCL-based miktoarm core-crosslinked amphiphilic star copolymers with hydrophobic interior,charged hydrophilic surface, and targeting motifs are elaborated. Such nanoscopic core-shell type architectures areenvisioned to be excellent candidates as drug delivery devices owing to the enhanced stability in biological fluids.Moreover, they may permit site-specific delivery of their potential cargo due to the presence of biologically activemoieties on the peripheries.

Poly(ε-caprolactone) - The Viable Scaffold for Construction of Intriguing Biomacromolecules

http://orbit.dtu.dk/ws/files/5699819/EUPOC_2011_Info_DTU_Library.pdf

Poly(ε-caprolactone) - The Viable Scaffold for Construction of Intriguing Biomacromolecules

Abstract

Similar works

Full text

Available Versions

Online Research Database In Technology