A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper

Baumbach, Tilo

Epple, Matthias

Ivlev, Sergei I.

Kluger, Petra J.

Loza, Kateryna

Melnik, Elizaveta

Shkarin, Roman

Shkarina, Svetlana

Surmenev, Roman A.

Surmeneva, Maria A.

Vacun, Gabriele

Weinhardt, Venera

Scientific Reports

To date, special interest has been paid to composite scaffolds based on polymers enriched with hydroxyapatite (HA). However, the role of HA containing different trace elements such as silicate in the structure of a polymer scaffold has not yet been fully explored. Here, we report the potential use of silicate-containing hydroxyapatite (SiHA) microparticles and microparticle aggregates in the predominant range from 2.23 to 12.40 µm in combination with polycaprolactone (PCL) as a hybrid scaffold with randomly oriented and well-aligned microfibers for regeneration of bone tissue. Chemical and mechanical properties of the developed 3D scaffolds were investigated with XRD, FTIR, EDX and tensile testing. Furthermore, the internal structure and surface morphology of the scaffolds were analyzed using synchrotron X-ray µCT and SEM. Upon culturing human mesenchymal stem cells (hMSC) on PCL-SiHA scaffolds, we found that both SiHA inclusion and microfiber orientation affected cell adhesion. The best hMSCs viability was revealed at 10 day for the PCL-SiHA scaffolds with well-aligned structure (~82%). It is expected that novel hybrid scaffolds of PCL will improve tissue ingrowth in vivo due to hydrophilic SiHA microparticles in combination with randomly oriented and well-aligned PCL microfibers, which mimic the structure of extracellular matrix of bone tissue

Kluger, Petra

Fraunhofer-ePrints

3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: High-resolution tomography and in vitro study

KITopen

English

3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: high-resolution tomography and in vitro study

1SCieNTifiC RepoRTS |         (2018) 8:17589  | DOI:10.1038/s41598-018-35952-wwww.nature.com/scientificreportsAuthor Correction: 3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: high-resolution tomography and in vitro studySvetlana Shkarina1,5, Roman Shkarin2,3, Venera Weinhardt  2,4,5, Elizaveta Melnik1, Gabriele Vacun6, Petra J. Kluger9, Kateryna Loza8, Matthias Epple8, Sergei I. Ivlev7, Tilo Baumbach2,5, Maria A. Surmeneva1 & Roman A. Surmenev1Correction to: Scientific Reports https://doi.org/10.1038/s41598-018-27097-7, published online 11 June 2018The original version of this Article contained errors. The name of Petra J. Kluger was incorrectly given as Petra Kluger.In addition, an incorrect Affiliation was listed for Petra J. Kluger. The correct Affiliation is listed below:Reutlingen University, Reutlingen, Germany.These errors have now been corrected in the HTML and PDF versions of this Article, and in the accompanying Supplementary Information file.1Research Center “Physical Materials Science and Composite Materials”, National Research Tomsk Polytechnic University, 634050, Tomsk, Russian Federation. 2Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. 3Institute for Applied Computer Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. 4Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany. 5Institute for Photon Science and Synchrotron Radiation, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. 6Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany. 7Fachbereich Chemie, Philipps-Universität Marburg, Marburg, Germany. 8Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Essen, Germany. 9Reutlingen University, Reutlingen, Germany. Correspondence and requests for materials should be addressed to M.A.S. (email: feja-mari@yandex.ru) or R.A.S. (email: rsurmenev@mail.ru)Published: xx xx xxxxOPENwww.nature.com/scientificreports/2SCieNTifiC RepoRTS |         (2018) 8:17589  | DOI:10.1038/s41598-018-35952-wOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018