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Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium-68 Positron Emission Tomography
Authors
Ahmadi P.
Fukase K.
+8 more
Kurbangalieva A.
Manabe Y.
Mukai H.
Nakamoto Y.
Pradipta A.
Tanaka K.
Watanabe Y.
Zouda M.
Publication date
1 January 2018
Publisher
Abstract
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Radiolabeled biomolecules with short half-life times are of increasing importance for positron emission tomography (PET) imaging studies. Herein, we demonstrate an improved and generalized method for synthesizing a [radiometal]-unsaturated aldehyde as a lysine-labeling probe that can be easily conjugated into various biomolecules through the RIKEN click reaction. As a case study, 68Ga-PET imaging of U87MG xenografted mice is demonstrated by using the 68Ga-DOTA-RGDyK peptide, which is selective to αVβ3 integrins
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Last time updated on 07/05/2019