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Antiviral Activity of Bacterial Extracellular Ribonuclease Against Single-, Double-Stranded RNA and DNA Containing Viruses in Cell Cultures
Authors
Efimova M.
Ilinskaya O.
+3 more
Mostafa A.
Shah Mahmud R.
Ulyanova V.
Publication date
1 January 2016
Publisher
Abstract
© 2016, Springer Science+Business Media New York.Binase, a small guanyl-preferring extracellular ribonuclease of Gram-positive non-pathogenic soil bacteria Bacillus pumilus. Binase is a well-known bacterial ribonuclease, and the most essential properties of the enzyme were characterized. Binase has demonstrated antiviral activity in various virus-infected animal models. Most experiments associated with binase treatment of virus-infected animals were performed using single stranded RNA viruses. It is still unclear, whether binase is able to inactivate the double stranded RNA virus. Moreover, the phenomenon of the antiviral activity of binase against the DNA containing virus in animal model is not explained. Here, we presented the experimental results reflecting binase effect towards eukaryotic cells infected with viruses containing different types of nucleic acids. The obtained data revealed the bacterial ribonuclease binase mode of action against single stranded RNA influenza A virus, double stranded RNA reovirus and DNA containing herpes virus to prove future application of new antiviral tool with a broad range of activity
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Kazan Federal University Digital Repository
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oai:dspace.kpfu.ru:net/115690
Last time updated on 07/05/2019
Kazan Federal University Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.kpfu.ru:net/146070
Last time updated on 07/05/2019