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Biochemical and immunological markers of autoimmune thyroiditis
Authors
Abramova Z.
Biktagirova E.
+5 more
Chuhlovina E.
Kravtsova O.
Sattarova L.
Skibo Y.
Vagapova G.
Publication date
1 January 2015
Publisher
Abstract
© 2015, Pleiades Publishing, Ltd. Correlations between biochemical and immunological markers of programmed cell death (apoptosis), and the functional state of the thyroid gland (hyperthyroidism, euthyroidism, hypothyroidism) have been investigated in autoimmune thyroiditis (AT) (also known as chronic autoimmune thyroiditis). Annexin V, TRAIL and TNFα, as well as DNA-hydrolyzing antibodies were used as the main markers. Increased levels of TRAIL were found in the serum of AT patients (hyperthyroidism > hypothyroidism > euthyroidism) compared with healthy individuals. The highest frequency of antibodies to denatured DNA (Abs-dDNA) had the highest frequency in AT patients (97%) compared with healthy controls. Among these patients, 75% had hyperthyroidism, 85% had hypothyroidism, and 84.7% had euthyroidism. Abs hydrolyzing activity demonstrated correlation dependence with symptoms of the thyroid dysfunction
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Kazan Federal University Digital Repository
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oai:dspace.kpfu.ru:net/100070
Last time updated on 07/05/2019
Kazan Federal University Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.kpfu.ru:net/141136
Last time updated on 07/05/2019