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Increasing permeability of phospholipid bilayer membranes to alanine with synthetic α-aminophosphonate carriers
Authors
Antipin I.
Danila D.
+3 more
Hubble H.
Pinkhassik E.
Wang X.
Publication date
1 January 2008
Publisher
Abstract
A series of aminophosphonates was synthesized, and their ability to carry alanine, a model hydrophilic molecule, across phospholipid bilayer membranes was evaluated. Aminophosphonates facilitate the membrane transport at moderate rates, which make them a suitable platform for the design of carriers for continuous drug release devices. © 2008 Elsevier Ltd. All rights reserved
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Last time updated on 07/05/2019