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Role of P2X and P2Y receptors in rat myocardial contractility during ontogeny
Authors
Anikina T.
Bilalova G.
Sitdikov F.
Zverev A.
Publication date
1 January 2007
Publisher
Abstract
Stable agonist of P2 receptors 2-methylthio-ATP and selective antagonists of P2X and P2Y receptors PPADS and reactive blue-2 were used for evaluation of the role of P2 receptors in positive contractile reaction of atrial and ventricular myocardium in rats. PPADS significantly moderated the effects of 2-methylthio-ATP in 14-, 21-, and 56-day-old rat pups, but potentiated them in 100-day-old rats. Under conditions of reactive blue-2 treatment, the positive effect of the agonist was preserved in the atria and ventricles in all age groups and was age-dependent. © Springer Science+Business Media, Inc. 2007
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Last time updated on 07/05/2019