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Molecular polymorphism of human enzymes as the basis of individual sensitivity to drugs. Supercomputer-assisted modeling as a tool for analysis of structural changes and enzymatic activity of proteins
Authors
Delacour H.
Kots E.
+7 more
Kulakova A.
Lockridge O.
Lushchekina S.
Makhaeva G.
Masson P.
Nemukhin A.
Varfolomeev S.
Publication date
1 January 2016
Publisher
Abstract
© 2016, Springer Science+Business Media New York.The nature of individual sensitivity to drugs associated with molecular polymorphism of human enzymes is discussed. The influence of molecular polymorphism on the activity of key human esterases, in particular, cholinesterases and carboxylesterase, responsible for hydrolytic metabolism of ester-containing drugs, is analyzed. A method was developed, which involves supercomputer-assisted modeling as a tool for assessment of molecular mechanism of the impact of point mutations on the catalytic activity of enzymes. This work is a part of a study aimed at elaboration of the concept and methods of personalized medicine
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Kazan Federal University Digital Repository
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oai:dspace.kpfu.ru:net/143462
Last time updated on 07/05/2019
Kazan Federal University Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dspace.kpfu.ru:net/114516
Last time updated on 07/05/2019