Cooper, GA

Hansen, MHH

Henryon, M

Jørgensen, HBH

Koop, BF

Lorenzen, Ellen

Sørensen, P

Online Research Database In Technology

                       General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.  • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal   If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.     Downloaded from orbit.dtu.dk on: Dec 17, 2017Response to Viral Infection differs between families of Rainbow TroutJørgensen, HBH; Sørensen, P; Cooper, GA; Lorenzen, Ellen; Hansen, MHH; Koop, BF; Henryon, MPublication date:2010Document VersionEarly version, also known as pre-printLink back to DTU OrbitCitation (APA):Jørgensen, H. B. H., Sørensen, P., Cooper, G. A., Lorenzen, E., Hansen, M. H. H., Koop, B. F., & Henryon, M.(2010). Response to Viral Infection differs between families of Rainbow Trout. Abstract from Animal Genomicsfor Animal Health, Paris, .RESPONSES TO VIRAL INFECTION DIFFERS BETWEEN FAMILIES OF RAINBOW TROUT  Submission for session 1: Understanding host-pathogen interactions and disease mechanisms with genomics-enabled tools   Jørgensen HBH1, Sørensen P1, Cooper GA2,4, Lorenzen E3, Lorenzen N3, Hansen MHH1, Koop BF4, Henryon M1,5  Address: 1University of Aarhus, Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, P.O. Box 50, DK-8830 Tjele, Denmark, 2 Institute of Ocean Sciences, Department of Fisheries and Oceans, 9860 West Saanich Rd., P.O.Box 6000, Sidney V8L 4B2, British Columbia, Canada, 3Technical University of Denmark, National Veterinary Institute, Hangovej 2, DK-8200 Aarhus N, Denmark, 4University of Victoria, Centre for Biomedical Research, Victoria V8W 3N5, British Columbia, Canada and 5Pig Research Center, Axeltorv 3, DK-1609 Copenhagen V, Denmark    We identified differences in gene expression profiles from two families of rainbow trout (Oncorhynchus mykiss), challenged with viral hemorrhagic septicaemia virus (VHSV). The two families represented trout of high and low resistance. We collected head kidney samples from the fish in a time-series from the day of bath challenge to day 16 following challenge. The samples were analysed using a 16K cDNA microarray for salmonids. In total, 642 and 556 transcripts from high and low resistance trout showed significantly different profiles between infected fish and non-infected control fish (FDR p=0.05). A closer look at expression profiles for differentially regulated genes of immunological interest reveal a number of differences in both the level and the timing of the responses in the two trout families. These results bring us closer to an understanding of the variability in the trout’s response to the intruding virus and indicate some key factors that provide the high-resistance trout with an advantage compared to the low-resistance trout.       Paris 31 May - 2 June "Animal Genomics for Animal Health" (.Presented by H.B.H. Jørgensen) 

Response to Viral Infection differs between families of Rainbow Trout

http://orbit.dtu.dk/ws/files/5223543/AGAH%202010%20HJ%20abstract%5B1%5D.pdf

Response to Viral Infection differs between families of Rainbow Trout

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