Osteoporosis : from pathophysiology to therapeutic approach

Abstract

Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Men as well as women are affected by osteoporosis, a disease that can be prevented and treated. In Japan, around 13 milion people already have osteoporosis or are high risk due to low bone mass. Hip and spine fractures are linked with increased mortality, and all fractures may lead to disability and reduced quality of life. Antiresorptive agents for osteoporosis are a cornerstone of therapy, and anabolic drugs have recently increased our options. Treatment of osteoporosis most commonly involves lifestyle changes and medications and aims to maximise bone density and reduce the risk of bone fracture

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