Recent progress and success for the treatment of IgA nephropathy and frequently relapsing and steroid-dependent nephrotic syndrome have been observed. Treatment with prednisolone,
immunosuppressive agents, anti-platelet drugs, and anti-coagulation early in the course of disease suppresses urinary protein excretion and reduces immunologic renal injury, and thereby prevents progression to renal failure in children with severe IgA nephropathy. This suggests that urinary screening of school children is important to detect children with severe IgA nephropathy. On the other hand, treatment with ciclosporin, calcineurin inhibitor, in children with steroid-dependent nephrotic syndrome induces complete remission and reduces frequency of recurrence. In addition, administration of ciclosporin reduces steroid-induced side effects including osteoporosis and short stature. In conclusion, these progresses of treatments have improved outcome and quality of lives of children with severe IgA nephropathy or steroid-dependent nephrotic syndrome
