Effect of intermittent liver ischemia on outcome in patients with hepatocellular carcinoma on liver cirrhosis

Abstract

The influence on postoperative liver function of intermittent normothermic hepatic ischemia in cirrhotic patients was studied retrospectively. The mean total ischemia time was 88 (range30 - 140) minutes in the hemi-hepatic occlusion group, and68 (range 10 - 187) minutes in the total occlusion group. There were no operative deaths due to hepatic failure. Postoperative liver function improved within 1 week of the opera-tion. There was no significant difference in the incidence of postoperative complications between the groups. Thus normothermic hepatic ischemia is tolerated for up to 180minutes in the cirrhotic liver when an intermittent technique (15 minutes clamped and5 minutes unclamped) is used

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