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Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Authors
Madeleine Cleal
Murilo S. de Abreu
+9 more
Konstantin A. Demin
Barbara D. Fontana
Brian Harvey
Allan V. Kalueff
Sergey L. Khatsko
Anton M. Lakstygal
Sebastian McBride
Matthew O. Parker
Konstantin N. Zabegalov
Publication date
1 January 2019
Publisher
Doi
Cite
Abstract
Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms. © 2019 Elsevier B.V
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